Open AccessInfluence of magnesium on excitability of neurons of different levels of their organization
Author(s) -
S. A. Antonenko
Publication year - 2019
Publication title -
journal of education, health and sport
Language(s) - English
Resource type - Journals
ISSN - 2391-8306
DOI - 10.12775/jehs.2019.09.11.029
Subject(s) - excitatory postsynaptic potential , neuroscience , glutamate receptor , acetylcholine , nmda receptor , neurotransmitter , dopamine , chemistry , biology , receptor , central nervous system , pharmacology , biochemistry , inhibitory postsynaptic potential
The article indicates that the hyper-excitability of neurons is associated with ionic imbalance of cell membranes, in which a number of trace elements are involved. The energy component of these processes is associated with the presence of magnesium (Mg) as a universal supplier of the latter. Mg supports the functioning of NMDA receptors, which does not allow the excitotoxic effects of glutamate, which triggers the mechanisms of Ca entry into the neuron and its death, to manifest itself. Mg stimulates the main excitatory neurotransmitter acetylcholine, regulates the release of serotonin, glycine, dopamine, thereby normalizing the extrapyramidal system, the spinal stem structures, and the final executive motor apparatus. Participates in the energy support of adaptation processes, the activation of central regulatory mechanisms, control the excess of catecholamines and corticosteroids, other hormones and mediators involved in stress reactions.