Immunoglobulin E associated systemic conditions

Immunoglobulin E (IgE) was the last immunoglobulin to be discovered, possibly secondaryto its low levels in plasma. Following extensive investigation, its role in the pathogenesis ofseveral diseases, most notably atopic conditions, has become evident. The immunologicpathways related to its synthesis and relation to effector cells is becoming more lucid. This hasallowed for the emergence of new medications that target different steps in its activity. In thisreview, we will summarize some of the most common systemic pathologies in which IgE hasa role in their etiology.