Open AccessA METABOLITE OF PROGESTERONE 11-DEOXYCORTICOSTERONE IN PLACENTA DURING EXACERBATION OF CYTOMEGALOVIRUS INFECTION
Author(s) -
И. В. Довжикова,
И. В. Довжикова,
Irina Andrievskaya,
Irina Andrievskaya,
Kseniya Petrova,
Kseniya Petrova,
Н. А. Ишутина,
Н. А. Ишутина,
Igor Gorikov,
Igor Gorikov
Publication year - 2019
Publication title -
bûlletenʹ fiziologii i patologii dyhaniâ
Language(s) - English
Resource type - Journals
ISSN - 1998-5029
DOI - 10.12737/article_5c89a8000f2931.69649220
Subject(s) - exacerbation , placenta , cytomegalovirus , pregnancy , medicine , gestation , preeclampsia , cytomegalovirus infection , endocrinology , obstetrics , human cytomegalovirus , fetus , immunology , biology , virus , herpesviridae , viral disease , genetics
The aim of the work is to study the content of 11-deoxycorticosterone in the placenta during pregnancy complicated by exacerbation of cytomegalovirus infection. Histochemical method was used to determine the content of 11-deoxycorticosterone in 72 placentas, including 37 cases from women with acute cytomegalovirus infection and simultaneously diagnosed moderate preeclampsia, and 35 placentas from women with exacerbation of chronic cytomegalovirus infection without concomitant diseases. The control group consisted of 30 placentas from mothers with chronic cytomegalovirus infection in the latent stage. It was found out that an increase in the content of 11-deoxycorticosterone in placenta by 25% in comparison with the control group occurred during gestation with an exacerbation of cytomegalovirus infection. A significant increase (by 40%) in the content of this hormone in the placenta was noted during the reactivation of the viral process accompanied by preeclampsia. We believe that an increase in the production of 11-deoxycorticosterone with mineralocorticotropic effect in the placenta could contribute to the development of hypertensive disorders in pregnancy complicated by cytomegalovirus infection.