METHOD FOR ASSESSING OF SEVERITY OF SYMPTOMS OF THE ENDOGENOUS INTOXICATION SYNDROME AND ASSOCIATED RESPIRATORY DISORDERS IN PATIENTS WITH COLORECTAL CANCER

The purpose of the research is to develop a method for assessing the severity of symptoms of the endogenous intoxication syndrome and associated respiratory disorders in patients with colorectal cancer. The study involved 86 patients (the main group included 51 patients with colorectal cancer, the control group 35 relatively healthy people). All patients were studied upon indicators of clinical blood test, and hematological indices of intoxication were calculated. In the patients of the main group, an assessment of the oxygen status parameters was done. The study revealed that 52.9% of patients with colorectal cancer have symptoms of endogenous intoxication syndrome and respiratory disorders of varying severity, which are accompanied by decrease in oxygen delivery to tissues, its increased consumption and utilization. As a result of the study, there was proposed a method for calculation of the integral index of intoxication as a parameter of expression of endogenous intoxication and associated respiratory disorders. Statistically significant values of the correlation coefficients of the proposed indicator of intoxication and oxygen status parameters suggest a high diagnostic significance of this index in patients with colorectal cancer. Moreover, the application of this method in everyday practice is simple for the doctor and safe for the patient.