Open AccessBONE REMODELING IN WOMEN WITH DIABETES MELLITUS
Author(s) -
Т. П. Бардымова,
Tatyana Bardymova,
Максим Мистяков,
Maksim Mistyakov,
Юлия Башарина,
Yuliya Basharina,
Е А Минаева,
Е А Минаева,
Александра Абзаева,
Александра Абзаева
Publication year - 2018
Publication title -
acta biomedica scientifica
Language(s) - English
Resource type - Journals
eISSN - 2587-9596
pISSN - 2541-9420
DOI - 10.12737/article_5a3a0d8f913509.24544012
Subject(s) - n terminal telopeptide , endocrinology , bone remodeling , medicine , osteocalcin , vitamin d and neurology , type 2 diabetes mellitus , type i collagen , osteoporosis , type 2 diabetes , bone resorption , procollagen peptidase , menopause , diabetes mellitus , chemistry , alkaline phosphatase , biochemistry , enzyme
Background. It is known that the type 2 diabetes mellitus (DM) and osteoporosis are more often diagnosed in senior
women. The condition of a bone tissue is accompanied by the metabolic violations that are typical for DM. The recent
researches established the multidirectional changes of bone remodeling markers in women with type 2 DM at differ-
ent age periods.
Aims: to study the condition of bone remodeling in women with type 2 DM at different age periods.
Materials and methods. We examined 27 women with type 2 DM, among them 15 were in the post-menopausal period
and 12 with preserved menstrual function. Levels of osteocalcin, N-terminal propeptide of type 1 collagen (P1NP), C-
terminal telopeptide of type 1 collagen (β-Crosslaps), 25-OH vitamin D, the ionized calcium were researched.
Results. The analysis showed that increase in β-Crosslaps levels, P1NP, levels of osteocaltcin were observed in women with
type 2 DM in the post-menopausal period, compared to parameters of women with type 2 DM with preserved menstrual function. Inverse correlation relation of osteocaltcin and 25-OH vitamin D was revealed in women with type 2 DM.
Conclusion. Significant increase in markers of osteosynthesis and osteoresorption in women with type 2 DM was
shown in the post-menopausal period compared with indicators of women with type 2 DM with preserved men-
strual function.