Open AccessTHE STATE OF LIPOPEROXIDATION PROCESSES IN BOYS WITH OBESITY
Author(s) -
М. А. Даренская,
M. A. Darenskaya,
Оксана Гаврилова,
Оксана Гаврилова,
Людмила Анатольевна Гребенкина,
Lyudmila Grebyonkina,
Olga V. Kravtsova,
Olga V. Kravtsova,
Л. В. Натяганова,
L. V. Natyaganova
Publication year - 2018
Publication title -
acta biomedica scientifica
Language(s) - English
Resource type - Journals
eISSN - 2587-9596
pISSN - 2541-9420
DOI - 10.12737/article_5a3a0d764250a4.87243362
Subject(s) - lipid peroxidation , obesity , antioxidant , medicine , childhood obesity , physiology , medical prescription , incidence (geometry) , endocrinology , chemistry , biochemistry , pharmacology , oxidative stress , physics , optics , overweight
The problem of obesity is extremely relevant for modern medical science and healthcare, and child and adolescent
obesity deserves special attention. It seems to be interesting to trace the interrelation of pathological processes in
obesity in the form of metabolic disorders at the level of the organism and at the cell level - disorders in the system
of lipid peroxidation. Studies in adolescent boys are relevant, as there has been a general increase in the incidence in
this age category. The purpose of the research was to study the state of the system “lipid peroxidation – antioxidant
protection” in adolescent boys with exogenous-constitutional obesity. 19 adolescent boys with obesity were examined
in comparison with the control group. Spectrophotometric and fluorometric methods of examination were used. An
increase in the level of secondary lipid peroxidation products – ketodienes and conjugated trienes (1.65 times) – was
revealed in adolescent boys with obesity. In the antioxidant defense system, differences in this group included reduced
values of α-tocopherol (1.42 times), retinol (1.51 times) and superoxide dismutase activity (1.19 times), in the absence
of statistically significant changes in the total antioxidant activity (AOA) in blood and components of glutathione status.
The revealed disorders allow to recommend the complex therapy including prescription of antioxidants and medicines
directed on normalization of lipid exchange at the given category of patients.