Open AccessENERGY-PROTECTIVE FUNCTION OF PLANT COMPOSITION IN THE EXPERIMENTAL DYSLIPOPROTEIDEMIA
Author(s) -
Лемза,
Sergey Lemza,
Торопова,
А. А. Торопова,
Верлан,
Н. В. Верлан,
Николаев,
S. Nikolaev,
Разуваева,
Ya. G. Razuvaeva,
Ерентуева,
Anna Erentueva
Publication year - 2016
Publication title -
bûlletenʹ vostočno-sibirskogo naučnogo centra
Language(s) - English
Resource type - Journals
ISSN - 1811-0649
DOI - 10.12737/21597
Subject(s) - composition (language) , bioenergetics , mitochondrion , energy metabolism , stimulation , metabolism , chemistry , biochemistry , medicine , biology , philosophy , linguistics
The influence of the plant composition on the functional state of rat hepatic mitochondria and biochemical indices of
energy metabolism was studied. Experiments were carried out on 42 white Wistar rats. The application of the plant
composition increases contingency between oxidation and phosphorylation, as well as coefficients of respiratory
stimulation and respiratory control by 17 % (р < 0.05) and 15 % (р < 0.05) respectively as compared to the control
group. The tested herbal medicine increases the ATP content by 29 % (р < 0.05) and improves the activity of pyruvate
kinase and H+-ATPase by 1.9 and 1.2 times respectively which indicates a partial restoration of energy metabolism in
hepatocytes. The results of the research allow us to recommend the plant composition for its further study as a potential
prospective hypolipidemic remedy for non-alcoholic fatty liver disease.