ENERGY-PROTECTIVE FUNCTION OF PLANT COMPOSITION IN THE EXPERIMENTAL DYSLIPOPROTEIDEMIA | Zendy

Лемза | Zendy; Sergey Lemza | Zendy; Торопова | Zendy; А. А. Торопова | Zendy; Верлан | Zendy; Н. В. Верлан | Zendy; Николаев | Zendy; Sergey Nikolaev | Zendy; Разуваева | Zendy; Я. Г. Разуваева | Zendy; Ерентуева | Zendy; Anna Erentueva | Zendy

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ENERGY-PROTECTIVE FUNCTION OF PLANT COMPOSITION IN THE EXPERIMENTAL DYSLIPOPROTEIDEMIA

Author(s) -

Лемза,

Sergey Lemza,

Торопова,

А. А. Торопова,

Верлан,

Н. В. Верлан,

Николаев,

Sergey Nikolaev,

Разуваева,

Я. Г. Разуваева,

Ерентуева,

Anna Erentueva

Publication year - 2016

Publication title -

бюллетень восточно-сибирского научного центра сибирского отделения российской академии медицинских наук

Language(s) - English

Resource type - Journals

ISSN - 1811-0649

DOI - 10.12737/21597

Subject(s) - composition (language) , bioenergetics , mitochondrion , energy metabolism , stimulation , chemistry , biochemistry , medicine , philosophy , linguistics

The influence of the plant composition on the functional state of rat hepatic mitochondria and biochemical indices of energy metabolism was studied. Experiments were carried out on 42 white Wistar rats. The application of the plant composition increases contingency between oxidation and phosphorylation, as well as coefficients of respiratory stimulation and respiratory control by 17 % (р < 0.05) and 15 % (р < 0.05) respectively as compared to the control group. The tested herbal medicine increases the ATP content by 29 % (р < 0.05) and improves the activity of pyruvate kinase and H+-ATPase by 1.9 and 1.2 times respectively which indicates a partial restoration of energy metabolism in hepatocytes. The results of the research allow us to recommend the plant composition for its further study as a potential prospective hypolipidemic remedy for non-alcoholic fatty liver disease.

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