Open AccessEFFECT OF SINGLE INTAKE OF EXOGENOUS HEPATOCYTES GROWTH INDUCER ON THE INDICES OF NON-SPECIFIC RESISTANCE UNDER CONDITIONS OF POSTRESECTION LIVER INJURY
Author(s) -
Прокопьев,
М. В. Прокопьев,
Koval,
Е. В. Коваль,
Курганский,
Ilya Kurganskiy,
Постовая,
Olga Postovaya,
Апарцин,
К. А. Апарцин,
Батунова,
Е. В. Батунова,
Зарицкая,
Larisa Zaritskaya,
Лепехова,
С. А. Лепехова,
Макошина,
Polina Makoshina
Publication year - 2016
Publication title -
bûlletenʹ vostočno-sibirskogo naučnogo centra
Language(s) - English
Resource type - Journals
ISSN - 1811-0649
DOI - 10.12737/21485
Subject(s) - phagocytosis , medicine , immune system , liver regeneration , inducer , hepatocyte growth factor , endocrinology , immunology , regeneration (biology) , biology , receptor , microbiology and biotechnology , biochemistry , gene
HGF is one of the factors taking part in regeneration and recovery of liver after injury. The article is dedicated to the study of influence of single HGF intake on the indices of non-specific immune response in rats after 70% liver resection in the early postoperative period. Research was conducted on 42 six-months white male Wistar rats of 250–300 g. It was revealed that level of segmentonuclear neutrophils and lymphocytes in the group with HGF intake stand at normal level on the 2nd day and normalizes to the 11th day that testifies to the decrease of inflammatory response. Increased level of leukocytes and monocytes is registered in the group with HGF intake. Also integrity of non-specific resistance in the early postoperative period on the 2nd day is registered. Suppression of phagocytosis indices with preservation of functional activity of phagocytes was registered to the 11th day.