Open AccessESTIMATION OF REPRODUCTIVE TOXICITY OF THE COMPLEX PLANT REMEDY �TIREOTON�
Author(s) -
���������,
И. П. Убеева,
��������,
Sergey Nikolaev,
���������,
Ya. G. Razuvaeva,
���������,
Н. В. Верлан,
���������,
Viktoriya Ayusheeva
Publication year - 2016
Publication title -
bûlletenʹ vostočno-sibirskogo naučnogo centra
Language(s) - English
Resource type - Journals
ISSN - 1811-0649
DOI - 10.12737/20618
Subject(s) - reproductive toxicity , toxicity , embryo , teratology , pregnancy , biology , physiology , toxicology , reproductive system , andrology , fetus , medicine , endocrinology , genetics
To study the probable negative influence of the complex remedy Tireoton on the reproductive function of the laboratory
animals the following tests have been carried out, namely the probable occurrence of embryo-toxicity, teratogenicity,
foetotoxicity and its influence on the postnatal development of the laboratory animals progeny. The experiments have
been carried out of the white Wistar rats. It has been established that the Tireoton at the doses of 75 and 750 mg/ kg
has no embryotoxic, teratogenic and fetotoxical effect. The introduction of the Tireoton at the dose of 750 mg/kg
since 6th to 19th day of pregnancy does not influence on the postnatal development of white rats progeny.