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Screening of new chemotherapeutic agents to combat fish diseases caused by parasitic diplomaragnidae (Diplomonadida Wenyon, 1926)
Author(s) -
Дмитриева,
S. N. Dmitrieva,
Бычкова,
Larisa Ivanovna Bychkova,
Гаврилин,
К. В. Гаврилин,
Мамыкина,
G. Mamykina
Publication year - 2016
Publication title -
rossijskij parazitologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2541-7843
pISSN - 1998-8435
DOI - 10.12737/18365
Subject(s) - mebendazole , albendazole , fenbendazole , metronidazole , anthelmintic , veterinary medicine , toxicology , pharmacology , biology , chemistry , zoology , medicine , antibiotics , surgery , microbiology and biotechnology , ecology
Objective of research. The purpose of the study – screening of new chemotherapeutic agents for the treatment of hexamita ornamental fish. Materials and methods. The test drugs were performed on juveniles of the discus Symphysodon discus a body mass of 15 g, spontaneously infested hexamitidae (Diplomonadida). 35 discus of the infected individuals were divided into 7 groups of 5 copies of the Fish 1, 2, 3, 4, 5, and 6th groups were appointed in the composition of granulated feed, respectively pyrimethamine at a dose of 50 mg/kg albendazole – 50, fenbendazole – 50, mebendazole – 10, magnesium sulfate – 500 and metronidazole in a dose of 50 mg/kg for 5 days. Fish 7 the first group was control and received feed without the drug. The effectiveness was considered after 5 days after the last Dachi medicated feed. Fish were dissected, the intestines were isolated, which were released from the food pulp, homogenized, and were studied by optical microscopy at a magnification of 180 times. Results and discussion. The number of examined in treated fish compared with the control decreased after the application of metronidazole by 95.5 %, mebendazole – 77.8, magnesium sulfate, which is 74.5, fenbendazole – by 56.6, albendazole – 50.5 and pyrimethamine – 24.4 %. Advanced for further testing are mebendazole, magnesium sulphate, fenbendazole and albendazole. The most effective was a basic drug – metronidazole. During the test degradation of fish were noted. Food activity was moderate at the level of 2% of ichthyomass. In fish treated with metronidazole, mebendazole and magnesium sulfate, have improved the condition.

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