
Efficacy of the supramolecular complex of Fenbendazole against nematodiasis in sheep
Author(s) -
Скира,
В Н Скира,
Душкин,
А. В. Душкин,
Чистяченко,
Yu. S. Chistyachenko,
Халиков,
С. С. Халиков,
Радионов,
А В Радионов,
Белова,
Е Е Белова,
Садова,
А К Садова,
Садов,
К. М. Садов,
Лимова,
Yu. Limova,
Варламова,
А И Варламова,
Архипов,
И. А. Архипов
Publication year - 2016
Publication title -
rossijskij parazitologičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2541-7843
pISSN - 1998-8435
DOI - 10.12737/18364
Subject(s) - fenbendazole , anthelmintic , benzimidazole , veterinary medicine , biology , medicine , chemistry , organic chemistry
Objective of research: to study the anthelmintic efficacy of the supramolecular complex of
Fenbendazole used against different nematode species in sheep
Materials and methods: Experiments were carried out on young sheep spontaneously
infected with gastrointestinal strongylates (48 head), Dictyocaulus filaria (42 head), Strongyloides
papillosus (21 head) и Trichocephalus ovis (24 head). In each helminthiasis, the supramolecular
complex of Fenbendazole was given once orally to sheep from various groups at the dose of 3,0;
2,0 and 1,0 mg a.i./kg in comparison with the base preparation Fenbendazole at the doses of 1,0
and 3,0 mg/kg. Sheep which didn’t receive the drug served as controls.
The efficacy of drugs was evaluated before and 18 days after dehelmintization according to the
results of coprolarvoscopic examination by flotation and G. Baermann methods. The registration
of drug activity was performed using the «control test».
Results and discussion: Anthelmintic efficacy was studied and a therapeutic dose for the
supramolecular complex of Fenbendazole produced by chemical mechanical technology using
the Drug Delivery System was determined. In gastrointestinal strongylatoses the supramolecular
complex against D. filaria. at the doses of 3,0; 2,0 and 1,0 mg a.i./kg showed the efficacy of 100;
93,4 and 78% , respectively.
The efficacy of supramolecular complex at the dose of 3,0 mg/kg against S. papillosus was
100 %, and against T. ovis - 98,3 % at 10–13% efficacy of the base preparation Fenbendazole at
the dose of 1,0 mg/kg. The therapeutic dose for the supramolecular complex at main nematodiasis
in sheep was 3,0 mg a.i./kg.