Open AccessIn Vitro Cell Culture Drug Resistance Testing
Author(s) -
Prabhavathy Mugala
Publication year - 2004
Publication title -
mapana journal of sciences
Language(s) - English
Resource type - Journals
ISSN - 0975-3303
DOI - 10.12723/mjs.4.8
Subject(s) - drug , drug resistance , pharmacology , drug development , antineoplastic drugs , medicine , biology , genetics
Drug development and screening programme for the identification Of a novel concer chemotherapeutic agent involves extensive preclin iCal evaluation of vast n umber Of chemicals for detection 0' their antineoplastic activity. The safety Of drugs the screening strategies (Freshney, 1992). The development Of drug resistance is a rnaior obstacle to effectiveness Of chemoåterapeutic treatment 0/ human tumors with cytotoxic agents. Drug resistance is described as a multifactor phenomenon, involving the expression Of defense ' factors