Conversion of 5-Hydroxytryptophan into Serotonin by Tryptophan Decarboxylase in Plants,Escherichia coli, and Yeast | Zendy

Munyoung Park | Zendy; Kiyoon Kang | Zendy; Sangkyu Park | Zendy; Kyoungwhan Back | Zendy

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Conversion of 5-Hydroxytryptophan into Serotonin by Tryptophan Decarboxylase in Plants,Escherichia coli, and Yeast

Author(s) -

Munyoung Park,

Kiyoon Kang,

Sangkyu Park,

Kyoungwhan Back

Publication year - 2008

Publication title -

bioscience biotechnology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.509

H-Index - 116

eISSN - 1347-6947

pISSN - 0916-8451

DOI - 10.1271/bbb.80220

Subject(s) - serotonin , 5 hydroxytryptophan , tryptophan , aromatic l amino acid decarboxylase , tryptophan hydroxylase , recombinant dna , biochemistry , yeast , genetically modified rice , glutamate decarboxylase , escherichia coli , enzyme , biology , chemistry , transgene , genetically modified crops , gene , serotonergic , amino acid , receptor

The L-tryptophan decarboxylase (TDC) gene of rice was heterologously expressed in various organisms. Transgenic rice overexpressing TDC showed accumulation of serotonin upon 5-hydroxytryptophan treatment, which was consistent with the in vitro 5-hydroxytryptophan decarboxylase enzyme activity of purified recombinant rice TDC in a pyridoxal phosphate-dependent manner. Recombinant yeast harboring TDC produced serotonin at the expense of the endogenous 5-hydroxytryptophan levels.

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