Enhancement of Radiation-induced Apoptosis by Preirradiation with Low-dose X-rays in Human Leukemia MOLT-4 Cells | Zendy

Zhiyun Chen | Zendy; Kazuo Sakai | Zendy

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Enhancement of Radiation-induced Apoptosis by Preirradiation with Low-dose X-rays in Human Leukemia MOLT-4 Cells

Author(s) -

Zhiyun Chen,

Kazuo Sakai

Publication year - 2004

Publication title -

journal of radiation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.643

H-Index - 60

eISSN - 1349-9157

pISSN - 0449-3060

DOI - 10.1269/jrr.45.239

Subject(s) - apoptosis , programmed cell death , low dose radiation , irradiation , leukemia , chemistry , cancer research , cell , radiation , nuclear medicine , microbiology and biotechnology , dose–response relationship , biology , biochemistry , medicine , immunology , endocrinology , physics , nuclear physics , quantum mechanics

The effects of low-dose preirradiation on the process of radiation-induced cell death were investigated in human leukemic MOLT-4 cells. By 0.2 Gy of X-rays given 12 h prior to a challenge dose of 5 Gy, the process of apoptosis was accelerated. The acceleration was associated with a certain increase in caspase 3 activity, a disruption of the mitochondrial transmembrane potential, and an accumulation of p53 proteins. This finding is in contrast to the radiation adaptive responses in which a small dose of preirradiation would induce certain radiation resistance and decrease the cell death after irradiation with higher doses.

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