Open AccessRadioprotective Effects of Sodium Tungstate on Hematopoietic Injury by Exposure to 60Co γ-rays in Wistar Rats
Author(s) -
Kaoru Sato,
Michiko Ichimasa,
Kosuke Miyahara,
Masae Shiomi,
Yoshikazu Nishimura,
Yusuke Ichimasa
Publication year - 1999
Publication title -
journal of radiation research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.643
H-Index - 60
eISSN - 1349-9157
pISSN - 0449-3060
DOI - 10.1269/jrr.40.101
Subject(s) - hematocrit , body weight , sodium , zoology , chemistry , dose rate , lethal dose , medicine , endocrinology , biology , radiochemistry , organic chemistry
Radioprotective effects of sodium tungstate (ST) on 60Co gamma-ray induced decrease in hematocrit value and in survival rate in Wistar strain male rats were examined. A long-term administration of ST (less than 150 mg/kg body weight/day) for 60-300 days had no significant effects on body and organs weights and survival days. The LD50/60 in 20 weeks old rats was 220 mg/kg body weight/day. Daily administration of 38, 75 or 150 mg from 7 days before and after irradiation to 60 days significantly mitigated the decrease in hematocrit values, especially at 23 days after irradiation (P < 0.05). The highest mitigation rate of the decrease in hematocrit value was observed in rats administered at a dose of 38 mg ST/day. Simultaneously, a dose of 38 mg ST/day inhibited lethal effect of 60Co gamma-rays significantly. The dose-reduction factor for survival of 38 mg ST administered rats was 1.14.