Open AccessThe translational roadmap of the gut models, focusing on gut-on-chip
Author(s) -
Michele Malaguarnera,
Miriam Graute,
Antoni Homs-Corbera
Publication year - 2021
Publication title -
open research europe
Language(s) - English
Resource type - Journals
ISSN - 2732-5121
DOI - 10.12688/openreseurope.13709.1
Subject(s) - organ on a chip , biology , immune system , gut flora , immunology , microfluidics , nanotechnology , materials science
It is difficult to model in vitro the intestine when seeking to include crosstalk with the gut microbiota, immune and neuroendocrine systems. Here we present a roadmap of the current models to facilitate the choice in preclinical and translational research with a focus on gut-on-chip. These micro physiological systems (MPS) are microfluidic devices that recapitulate in vitro the physiology of the intestine. We reviewed the gut-on-chips that had been developed in academia and industries as single chip and that have three main purpose: replicate the intestinal physiology, the intestinal pathological features, and for pharmacological tests.