Open AccessPharmacological pain management in patients with chronic hepatic disease
Author(s) -
László Irsay,
Alexandra Checiches,
Dănuț Perja,
Ileana Monica Borda,
Gabriela Dogaru,
Rodica Ana Ungur,
Alina Deniza Ciubean,
Viorela Mihaela Ciortea
Publication year - 2019
Publication title -
balneo research journal
Language(s) - English
Resource type - Journals
eISSN - 2069-7619
pISSN - 2069-7597
DOI - 10.12680/balneo.2019.249
Subject(s) - medicine , cirrhosis , hepatic encephalopathy , hepatic function , pharmacokinetics , chronic hepatic , liver disease , disease , chronic liver disease , intensive care medicine , hepatic dysfunction , impaired renal function , encephalopathy , liver function , pharmacology , renal function
The liver has a central role in the pharmacokinetics (absorption, distribution, elimination, etc.) of drugs. With hepatic insufficiency, the metabolism of drugs decreases, which accumulates metabolically or toxic active products. Some medicines can aggravate a pre-existing liver disease. Medicines used in this group of patients (especially diuretics and centrally acting preparations) can often cause impaired renal function or hepatic encephalopathy. The general principles of assessment, pain management and analgesia should be prescribed taking into account the Word Health Organization (WHO) recommendations for these patients, with careful and frequent monitoring of patient progress during treatment administration.Key words: hepatotoxicity, hepatic dysfunction, cirrhosis, pain medication,