Open AccessVincristine induced neurotoxicity in children who underwent chemotherapy for acute lymphoblastic leukemia and Wilms tumor
Author(s) -
Muhammad Adil,
Zulfıqar Ali,
Uzma Arshad,
Usman Fawad
Publication year - 2021
Publication title -
pakistan journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.316
H-Index - 30
eISSN - 1682-024X
pISSN - 1681-715X
DOI - 10.12669/pjms.37.5.4169
Subject(s) - medicine , vincristine , chemotherapy , wilms' tumor , side effect (computer science) , neurotoxicity , pediatrics , regimen , surgery , cyclophosphamide , toxicity , computer science , programming language
Vincristine has been used as chemotherapeutic agent for many decades. It implements its function by inhibiting the duplication of tumor cells by destroying the DNA. However, like all other drugs, its administration is not without any side effects. The most important of these are being the neurotoxic side effects. This study evaluated the degree of neurotoxicity induced by vincristine in children who underwent chemotherapy for acute lymphoblastic leukemia and Wilms tumor.