Open AccessPre-operative serum TSH levels: A risk factor for advanced metastatic differentiated thyroid carcinoma
Author(s) -
Sumera Batool,
Muhammad Shakir Afridi,
Adeel Khoja,
Najmul Islam
Publication year - 2019
Publication title -
pakistan journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.316
H-Index - 30
eISSN - 1682-024X
pISSN - 1681-715X
DOI - 10.12669/pjms.35.5.704
Subject(s) - medicine , thyroid carcinoma , thyroid cancer , thyroid , stage (stratigraphy) , univariate analysis , oncology , metastasis , risk factor , incidence (geometry) , lymphovascular invasion , cancer , lymph node , thyroglobulin , thyroid stimulating hormone , multivariate analysis , paleontology , physics , optics , biology
As the thyroid cancer incidence is increasing, the search for its risk factor is becoming more important. Serum thyroid stimulating hormone (TSH) levels being a growth factor for normal thyroid tissue, is also considered as growth promotor of cancer cells. In our study we aimed for pre-operative serum TSH levels of Differentiated thyroid cancers (DTC) done before their first surgery and determined its association with advanced disease in terms of stage, multifocal disease, lymph node involvement and distant metastasis.