Open AccessCirculating miR-21 as a prognostic and predictive biomarker in oral squamous cell carcinoma
Author(s) -
Nosheen Mahmood,
Muhammad Hanif,
Alia Ahmed,
Qamar Jamal,
Shamim Mushtaq,
Adnan Khan,
Muhammad Saqib
Publication year - 2019
Publication title -
pakistan journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.316
H-Index - 30
eISSN - 1682-024X
pISSN - 1681-715X
DOI - 10.12669/pjms.35.5.331
Subject(s) - medicine , microrna , biomarker , cancer , oncology , basal cell , stage (stratigraphy) , metastasis , real time polymerase chain reaction , cancer research , pathology , gene , biology , paleontology , biochemistry
The high-throughput analysis of circulating microRNAs (miRNAs) is an active area of biomarker research. The oral cancer remains a common cancer among Pakistani males that continues to present at an advance stage, thus exhibiting poor survival. MiRNA 21 (miR-21) is the most consistently over-expressed miRNA in different types of tumor tissues. However, information regarding expression of miR-21 in plasma remains to be resolved. Therefore, present study was designed to investigate if miR-21 was expressed in plasma of patients with oral cancer, and further explore its diagnostic and prognostic potential.