Open AccessAssociation of RAGE gene polymorphism with type 2 diabetes mellitus in local population
Author(s) -
Saba Zulfiqar,
Fatma Hussain,
Amer Jamil,
Nisar Ahmed
Publication year - 2018
Publication title -
pakistan journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.316
H-Index - 30
eISSN - 1682-024X
pISSN - 1681-715X
DOI - 10.12669/pjms.341.14359
Subject(s) - medicine , rage (emotion) , polymorphism (computer science) , type 2 diabetes mellitus , gene , diabetes mellitus , genetics , gene polymorphism , population , allele , endocrinology , environmental health , neuroscience , biology
Type-2 diabetes mellitus (T2DM) is an endocrine disease having a significant genetic component. Polymorphisms of many genes may affect hereditary vulnerability of the disease that is characterized by insulin resistance and islet disorder. As the genetic basis of T2DM can vary between ethnic groups, it is important to investigate the genetic link of T2DM in Pakistani populace. This study was aimed to assess the association of receptor for advanced glycation end product (RAGE) gene polymorphism (-429T>C) with Type-2 diabetes mellitus within local populace.