Open AccessHatosplenic mucormycosis post autologous stem cell transplant
Author(s) -
Samia Yasmeen,
Omer Waqas,
Javeria Munir,
Faisal Sultan,
Abdul Hameed
Publication year - 2017
Publication title -
pakistan journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.316
H-Index - 30
eISSN - 1682-024X
pISSN - 1681-715X
DOI - 10.12669/pjms.333.12311
Subject(s) - medicine , mucormycosis , stem cell , lymphoma , hematopoietic stem cell transplantation , hematopoietic stem cell , histopathology , surgery , biopsy , transplantation , radiology , haematopoiesis , pathology , genetics , biology
Mucormycosis is a life threatening fungal infection and remains an important cause of morbidity and mortality in immunocompromised patients after hematopoietic stem cell transplant. We report here a case of hepatosplenic mucormycosis in a patient after autologous stem cell transplant. A young man with anaplastic large cell lymphoma underwent autologous hematopoietic stem cell transplant after achieving complete remission with standard chemotherapy and consolidative radiotherapy. He was found to have incidental hepatosplenic hypodensities on follow up imaging, that were proved to be mucormycosis on histopathology after getting CT-guided biopsy of splenic lesions. He was treated with intravenous amphotericin-B followed by complete radiological resolution of hepatosplenic lesions. Although these infections are often life threatening but limited disease may have better outcome if diagnosed and treated early and aggressively.