Open AccessMetformin attenuate PTZ-induced apoptotic neurodegeneration in human cortical neuronal cells
Author(s) -
Fehmida Bibi,
Ikram Ullah,
Myeong Ok Kim,
Muhammad Imran Naseer
Publication year - 2017
Publication title -
pakistan journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.316
H-Index - 30
eISSN - 1682-024X
pISSN - 1681-715X
DOI - 10.12669/pjms.333.11996
Subject(s) - neuroprotection , metformin , medicine , neurodegeneration , apoptosis , pharmacology , programmed cell death , pentylenetetrazol , cell culture , neuroscience , endocrinology , biology , diabetes mellitus , epilepsy , biochemistry , anticonvulsant , genetics , disease , psychiatry
Seizures are one of the neurodegenerative disorders of human being. Metformin has antioxidant properties and commonly used as an oral antidiabetic drug. The current study was aimed to observe the neuroprotective effect of metformin against PTZ-induced apoptotic neurodegeneration in human cortical neuronal cell culture.