Open AccessIncreased association between codon 399 polymorphism in the X-ray repair cross-complementing group 1 gene and prostate cancer risk in Asians: A study of 4,479 cases and 4,281 controls
Author(s) -
Yuanyuan Mi,
Xiaoming You,
Ling Zhu,
Na Feng
Publication year - 2015
Publication title -
pakistan journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.316
H-Index - 30
eISSN - 1682-024X
pISSN - 1681-715X
DOI - 10.12669/pjms.315.7510
Subject(s) - xrcc1 , medicine , odds ratio , prostate cancer , allele , subgroup analysis , confidence interval , genetics , oncology , genotype , gene , bioinformatics , cancer , single nucleotide polymorphism , biology
The polymorphism in codon 399 of the X-ray repair cross-complementing group 1 (XRCC1) gene may subtly alter structure of DNA repair enzymes and modulate the repair capacity. Impaired DNA repair can lead to the development of cancers such as prostate cancer (PCA). Although the association between the XRCC1 codon 399 polymorphism and PCA risk has been extensively reported, the results have been ambiguous.