Open AccessDesigning Adsorption Centres for Biological Active Molecules on a Silica Surface
Author(s) -
L. А. Belyakova,
A. M. Varvarin,
D. Yu. Lyashenko,
O. V. Khora
Publication year - 2005
Publication title -
adsorption science and technology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.682
H-Index - 36
eISSN - 2048-4038
pISSN - 0263-6174
DOI - 10.1260/026361705776316596
Subject(s) - chemistry , adsorption , cyclodextrin , thermogravimetric analysis , titration , elemental analysis , grafting , molecule , infrared spectroscopy , organic chemistry , chemical structure , inclusion compound , silica gel , polymer
The chemical interaction between the surface of hydroxylated or aminated silicas and β-cyclodextrin, mono-tosyl-β-cyclodextrin and the bromine derivative of heptakis-[6- O-( p-tosyl-β-cyclodextrin)] has been investigated using IR spectroscopy, thermogravimetric analysis with programmed heating, pH titration, weight adsorption method, elemental analysis and quantitative chemical analysis of the surface compounds. The optimum conditions for chemical grafting of β-cyclodextrins onto the silica surface were established. The formation of supramolecular structures, viz. inclusion complexes between immobilized β-cyclodextrin and the hormone of pineal gland (melatonin), on the surface of highly dispersed silicas of 1:1 composition was demonstrated.