Open AccessNovel pulmonary vascular imaging signs in COVID-19: pathophysiology, significance and management
Author(s) -
Arshed Hussain Parry,
Abrar Ahad Wani
Publication year - 2021
Publication title -
bjr|open
Language(s) - English
Resource type - Journals
ISSN - 2513-9878
DOI - 10.1259/bjro.20210001
Subject(s) - covid-19 , medicine , pathological , pathophysiology , renin–angiotensin system , pathology , disease , blood pressure , infectious disease (medical specialty)
A growing body of evidence points to the frequent involvement of pulmonary microvessels in COVID-19 which was recognized first on CT, and subsequently demonstrated by clinical and pathological studies. Microvasculopathy occurring chiefly from endothelial and pericyte damage with resultant disruption of immune, thrombotic and renin–angiotensin–aldosterone balance leads to a constellation of clinical and biochemical derangements. Exploration of potential therapies directed at normalizing the vascular health can prove a major boon in the treatment of COVID-19.