Open AccessA case of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) presenting as post-infectious manifestation of SARS-CoV-2 infection
Author(s) -
Ishwariya Rajendran,
Madhu Dutta Natarajan,
Pooja Narwani,
Omran Alzouabi,
Khalil Kawafi,
Navin Khanna
Publication year - 2021
Publication title -
bjr case reports
Language(s) - English
Resource type - Journals
ISSN - 2055-7159
DOI - 10.1259/bjrcr.20210020
Subject(s) - cadasil , leukoencephalopathy , hyperintensity , medicine , encephalopathy , pathology , acute disseminated encephalomyelitis , progressive multifocal leukoencephalopathy , leukoaraiosis , white matter , encephalitis , dementia , magnetic resonance imaging , disease , multiple sclerosis , virology , radiology , immunology , virus
White matter hyperintensities (WMHs) lacunar infarcts and cerebral microbleeds are well-established features associated with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Increasing case reports and series recounts a wide array of neurological manifestations of COVID-19 including acute cerebrovascular disease, encephalopathy, encephalitis and demyelination. Recently association between COVID-19 and CADASIL has been identified. We describe an unusual case of CADASIL diagnosed as a possible post-infectious manifestation of COVID-19 patient with imaging features closely resembling post-infectious encephalomyelitis.