Open AccessElevated glycine detected on in vivo magnetic resonance spectroscopy in a breast cancer patient: case report and literature review
Author(s) -
Almir Galvão Vieira Bitencourt,
Katja Pinker,
Sunitha B. Thakur
Publication year - 2020
Publication title -
bjr case reports
Language(s) - English
Resource type - Journals
ISSN - 2055-7159
DOI - 10.1259/bjrcr.20190090
Subject(s) - in vivo , glycine , ex vivo , breast cancer , magnetic resonance imaging , in vivo magnetic resonance spectroscopy , cancer , nuclear magnetic resonance , medicine , spectroscopy , nuclear magnetic resonance spectroscopy , chemistry , pathology , cancer research , biochemistry , biology , radiology , amino acid , microbiology and biotechnology , physics , quantum mechanics
Magnetic resonance spectroscopy (MRS) is a promising non-invasive diagnostic method that can detect and quantify endogenous tissue metabolites. High glycine levels obtained from ex vivo breast MRS have been associated with poor prognosis; however, glycine evaluation has not been reported regarding in vivo MRS. We report our finding in a breast cancer patient in whom pre-treatment but not post-treatment in vivo MRS showed elevated glycine and discuss the implications of this finding.