Open AccessCombination of dabrafenib and radiotherapy: could skin toxicity be affected by different irradiation techniques?
Author(s) -
Daniela Alterio,
Giulia Marvaso,
Annamaria Ferrari,
Ombretta Alessandro,
Emilia Cocorocchio,
Pier Francesco Ferrucci,
Roberto Orecchia,
Barbara Alicja JereczekFossa
Publication year - 2016
Publication title -
bjr case reports
Language(s) - English
Resource type - Journals
ISSN - 2055-7159
DOI - 10.1259/bjrcr.20150493
Subject(s) - concomitant , radiation therapy , toxicity , medicine , melanoma , acute toxicity , dabrafenib , dermatology , oncology , metastatic melanoma , cancer research , vemurafenib
The prognosis of patients with metastatic melanoma is changing owing to the introduction of selective BRAF inhibitors combined with MEK inhibitors. Management of these patients continues to be a challenge, especially when systemic therapy has to be combined with concomitant radiotherapy, particularly owing to skin toxicity. Here we report a case of a patient who underwent concomitant treatment for two vertebral sites using two different radiotherapy techniques. An unexpected acute skin toxicity was reported at one of the treated sites. This finding might be owing to the different absorbed dose to the subcutaneous tissues linked with the technique of irradiation.