Open AccessPilomyxoid astrocytoma of the corpus callosum presenting with primary haemorrhage in an adolescent
Author(s) -
MariaLongo,
J. Adams Perez,
FrancineOliveira,
AntunesApio,
VedolinLeonardo,
Juliana AvilaDuarte
Publication year - 2017
Publication title -
bjr case reports
Language(s) - English
Resource type - Journals
ISSN - 2055-7159
DOI - 10.1259/bjrcr.20150020
Subject(s) - corpus callosum , pilocytic astrocytoma , medicine , astrocytoma , pathology , third ventricle , white matter , pathological , lesion , fourth ventricle , magnetic resonance imaging , expansive , anatomy , radiology , glioma , compressive strength , materials science , cancer research , composite material
A 17-year-old male patient with history of intraventricular haemorrhage in 2007 underwent a brain MRI scan in 2013 owing to headache. Brain MRI scan showed an expansive lesion adjacent to the left lateral ventricle infiltrating the anterior portion of the corpus callosum. After surgery, pathology confirmed a pilomyxoid astrocytoma (PMA), an aggressive subtype of astrocytoma that occurs predominantly in the hypothalamic-chiasmatic region. On imaging, PMA presents as a tumour isointense on T 1 , hyperintense on T 2 that enhanced heterogeneously with contrast. The T 2 signal is higher than pilocytic astrocytoma, which indicates the presence of myxoid matrix. These findings on MRI scan have a direct correlation with a specific pathological finding—monomorphic proliferation of piloid cells in a mucopolysaccharide-rich matrix. These characteristics associated with the absence of Rosenthal fibres or eosinophilic granules indicated the diagnosis of PMA. To our knowledge, this is the first case report of PMA affecting the corpus callosum in an adolescent.