Open AccessSome pathogenic aspects of murine sarcoma virus (Moloney) in rats
Author(s) -
K. Perk,
Harvie L. Sims
Publication year - 1975
Publication title -
laboratory animals
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.62
H-Index - 63
eISSN - 1758-1117
pISSN - 0023-6772
DOI - 10.1258/002367775780994871
Subject(s) - virus , sarcoma , inoculation , biology , virology , lethal dose , host (biology) , pathology , immunology , medicine , genetics , toxicology
The oncogenic effect of the murine sarcoma virus (Moloney) was tested in rats. Host-age and virus-dose dependent variations in the pathogenic spectrum were found. Four tumour 'stages' were described: progressively lethal; lethal after long stationary period; complete tumour regression; tumour reoccurrence after complete regression. Virus recovery was highest from the progressively growing tumours and in the reoccurred neoplasms, while no virus was found in stationary tumours or in those sites where regression had occurred. Tumour onset and death was more rapid and frequent when inoculation of the virus was in muscle-rich tissues. When inoculation was into different visceral organs or intravenously, tumour development still occurred primarily in muscle tissue.