Open AccessMediation of Arterial Stiffness for Hyperuricemia-Related Decline of Cardiac Systolic Function in Healthy Men
Author(s) -
Hiroki Nakano,
Kazuki Shiina,
Takamichi Takahashi,
Kento Kumai,
Masatsune Fujii,
Yoichi Iwasaki,
Chisa Matsumoto,
Taishiro Chikamori,
Akira Yamashina,
Hirofumi Tomiyama
Publication year - 2021
Publication title -
circulation reports
Language(s) - English
Resource type - Journals
ISSN - 2434-0790
DOI - 10.1253/circrep.cr-21-0013
Subject(s) - arterial stiffness , cardiology , medicine , hyperuricemia , observational study , mediation , blood pressure , uric acid , political science , law
Background: This prospective observational study examined whether hyperuricemia may be associated with impaired left ventricular (LV) systolic function and increased cardiac load resulting from increased arterial stiffness. Methods and Results: In 1,880 middle-aged (mean [±SD] age 45±9 years) healthy men, serum uric acid (UA) levels, pre-ejection period/ejection time (PEP/ET) ratio, serum N-terminal pro B-type natriuretic peptide (NT-proBNP) levels, and brachial-ankle pulse wave velocity (baPWV) were measured at the start and end of the 3-year study period. Linear regression analysis revealed that serum UA levels measured at baseline were significantly associated with the PEP/ET ratio, but not with serum NT-proBNP levels, measured at baseline (β=0.73×10 -1 , P<0.01) and at the end of the study period (β=0.68×10 -1 , P<0.01). The change in the PEP/ET ratio during the study period was significantly greater in the High-UA (UA >7 mg/dL in 2009 and 2012) than Low-UA (UA ≤7 mg/dL in 2009 and 2012) group. Mediation analysis demonstrated both direct and indirect (via increases in baPWV) associations between serum UA measured at baseline and the PEP/ET ratio measured at the end of the study period. Conclusions: In healthy middle-aged Japanese men, hyperuricemia may be associated with an accelerated decline in ventricular systolic function, both directly and indirectly, via increases in arterial stiffness.