Effects of α-lipoic Acid on mtDNA Damage after Isolated Muscle Contractions | Zendy

Mark Fogarty | Zendy; Giuseppe De Vito | Zendy; Ciara Hughes | Zendy; George Burke | Zendy; J. C. Brown | Zendy; Jane McEneny | Zendy; David Brown | Zendy; Conor McClean | Zendy; Gareth W. Davison | Zendy

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Effects of α-lipoic Acid on mtDNA Damage after Isolated Muscle Contractions

Author(s) -

Mark Fogarty,

Giuseppe De Vito,

Ciara Hughes,

George Burke,

J. C. Brown,

Jane McEneny,

David Brown,

Conor McClean,

Gareth W. Davison

Publication year - 2013

Publication title -

medicine and science in sports and exercise

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.703

H-Index - 224

eISSN - 1530-0315

pISSN - 0195-9131

DOI - 10.1249/mss.0b013e31828bf31e

Subject(s) - lipoic acid , oxidative stress , medicine , antioxidant , endocrinology , lipid peroxidation , muscle biopsy , chemistry , dna damage , biochemistry , biopsy , dna

Although pharmacological antioxidants have previously been investigated for a prophylactic effect against exercise oxidative stress, it is not known if α-lipoic acid supplementation can protect against DNA damage after high-intensity isolated quadriceps exercise. This randomized controlled investigation was designed to test the hypothesis that 14 d of α-lipoic acid supplementation can attenuate exercise-induced oxidative stress.

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