Open AccessEffects of α-lipoic Acid on mtDNA Damage after Isolated Muscle Contractions
Author(s) -
Mark Fogarty,
Giuseppe De Vito,
Ciara Hughes,
George Burke,
J. C. Brown,
Jane McEneny,
David M. Brown,
Conor McClean,
Gareth W. Davison
Publication year - 2013
Publication title -
medicine and science in sports and exercise
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.703
H-Index - 224
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1249/mss.0b013e31828bf31e
Subject(s) - lipoic acid , oxidative stress , medicine , antioxidant , endocrinology , lipid peroxidation , muscle biopsy , chemistry , dna damage , biochemistry , biopsy , dna
Although pharmacological antioxidants have previously been investigated for a prophylactic effect against exercise oxidative stress, it is not known if α-lipoic acid supplementation can protect against DNA damage after high-intensity isolated quadriceps exercise. This randomized controlled investigation was designed to test the hypothesis that 14 d of α-lipoic acid supplementation can attenuate exercise-induced oxidative stress.