Open AccessAndrogens Affect Myogenesis In Vitro and Increase Local IGF-1 Expression
Author(s) -
Nicholas Sculthorpe,
Andrew Solomon,
Andrea Sinanan,
Pierre-Marc Bouloux,
Fergal Grace,
Mark P. Lewis
Publication year - 2012
Publication title -
medicine and science in sports and exercise
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.703
H-Index - 224
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1249/mss.0b013e318237c5c0
Subject(s) - endocrinology , medicine , myogenesis , androgen receptor , androgen , anabolism , skeletal muscle , flutamide , biology , messenger rna , muscle hypertrophy , testosterone (patch) , growth factor , receptor , chemistry , hormone , gene , biochemistry , prostate cancer , cancer
The mechanism whereby anabolic androgens are associated with hypertrophy of skeletal muscle is incompletely understood but may involve an interaction with locally generated insulin-like growth factor (IGF) 1. The present investigation utilized a cell culture model of human skeletal muscle-derived cell maturation to test the hypothesis that androgens increase differentiation of human muscle precursor cells in vitro and to assess effects of androgen with or without IGF-1 on IGF-1 messenger RNA (mRNA) expression in human muscle precursor cells.