Open AccessExercise Does Not Attenuate Early CAD Progression in a Pig Model
Author(s) -
Arturo A. ArceEsquivel,
Kurt V. Kreutzer,
James W. E. Rush,
James R. Turk,
M. Harold Laughlin
Publication year - 2012
Publication title -
medicine and science in sports and exercise
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.703
H-Index - 224
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1249/mss.0b013e318228879b
Subject(s) - coronary arteries , medicine , immunohistochemistry , cardiology , coronary artery disease , coronary atherosclerosis , oxidative stress , ex vivo , phenotype , artery , biology , biochemistry , gene , in vitro
This study was designed to examine the effects of high-fat (HF) diet and subsequent exercise training (Ex) on coronary arteries of an animal model of early stage CAD. We hypothesized that HF diet would induce early stage disease and promote a proatherogenic coronary phenotype, whereas Ex would blunt disease progression and induce a healthier anti-inflammatory environment reflected by the increased expression of antioxidant capacity and the decreased expression of inflammatory markers in both the macrovasculature and the microvasculature of the coronary circulation.