Open AccessExercise-Induced Oxidative DNA Damage and Lymphocytopenia in Sedentary Young Males
Author(s) -
Yuko Tanimura,
Kazuhiro Shimizu,
Kai Tanabe,
Takeshi Otsuki,
Ryohei Yamauchi,
Y Matsubara,
Motoyuki Iemitsu,
Seiji Maeda,
Ryuichi Ajisaka
Publication year - 2008
Publication title -
medicine and science in sports and exercise
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.703
H-Index - 224
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1249/mss.0b013e31817242cf
Subject(s) - lymphocytopenia , dna damage , lymphocyte , oxidative stress , medicine , reactive oxygen species , endocrinology , superoxide , immunology , chemistry , biology , biochemistry , dna , enzyme
Post high-intensity exercise lymphocytopenia is well documented, but its underlying mechanisms have not been fully elucidated. A possible mechanism is a reactive oxygen species-induced DNA damage after high-intensity exercise. Furthermore, lymphocyte apoptosis related to DNA damage might contribute to exercise-induced lymphocytopenia.