Open AccessLifelong Exercise in Age Rats Improves Skeletal Muscle Function and MicroRNA Profile
Author(s) -
Hao-En Gao,
Fanghui Li,
Tian Xie,
Song Ma,
Yi-Bo Qiao,
Da-Shuai Wu,
Lei Sun
Publication year - 2021
Publication title -
medicine and science in sports and exercise
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.703
H-Index - 224
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1249/mss.0000000000002661
Subject(s) - skeletal muscle , sarcopenia , endocrinology , medicine , autophagy , microrna , muscle atrophy , atrophy , pi3k/akt/mtor pathway , downregulation and upregulation , protein kinase b , biology , apoptosis , gene , genetics
Lifelong exercise is known to attenuate sarcopenia (age-associated reduction in muscle mass and function); however, the underlying molecular mechanisms remain unclear. As microRNAs are widely involved in the regulation of skeletal muscle growth and development, we aimed to evaluate the effects of lifelong regular exercise on age-related alterations in muscle microRNA expression profiles as well as on skeletal muscle atrophy, apoptosis, and mitochondria and autophagy dysfunction.