Open AccessFemale Athletes Genetically Susceptible to Fatigue Fracture Are Resistant to Muscle Injury: Potential Role of COL1A1 Variant
Author(s) -
Eri MiyamotoMikami,
Hiroshi Kumagai,
Kumpei Tanisawa,
Yuki Taga,
Kosuke Hirata,
Naoki Kikuchi,
Nobuhiro Kamiya,
Ryoko Kawakami,
Taishi Midorikawa,
Takanobu Kawamura,
Ryo Kakigi,
Toshiharu Natsume,
Hirofumi Zempo,
Koya Suzuki,
Yoshimitsu Kohmura,
Kazunori Mizuno,
Suguru Torii,
Shizuo Sakamoto,
Koichiro Oka,
Mitsuru Higuchi,
Hisashi Naito,
Naokazu Miyamoto,
Noriyuki Fuku
Publication year - 2021
Publication title -
medicine and science in sports and exercise
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.703
H-Index - 224
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1249/mss.0000000000002658
Subject(s) - odds ratio , medicine , hazard ratio , muscle biopsy , allele , endocrinology , confidence interval , genotype , gastroenterology , cardiology , biopsy , genetics , biology , gene
We aimed to investigate the hypothesis that type I collagen plays a role in increasing bone mineral density (BMD) and muscle stiffness, leading to low and high risks of fatigue fracture and muscle injury, respectively, in athletes. As a potential mechanism, we focused on the effect of the type I collagen alpha 1 chain gene (COL1A1) variant associated with transcriptional activity on bone and skeletal muscle properties.