Open AccessExercise Intolerance in Cystic Fibrosis: Importance of Skeletal Muscle
Author(s) -
Paula RodriguezMiguelez,
Nichole Seigler,
Haruki Ishii,
Reva Crandall,
Kathleen T. McKie,
Caralee Forseen,
Ryan A. Harris
Publication year - 2020
Publication title -
medicine and science in sports and exercise
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.703
H-Index - 224
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1249/mss.0000000000002521
Subject(s) - exercise intolerance , skeletal muscle , sildenafil , medicine , cystic fibrosis , cardiology , population , hemodynamics , chronotropic , physical exercise , cgmp specific phosphodiesterase type 5 , endocrinology , heart failure , heart rate , blood pressure , environmental health
Exercise intolerance, evaluated by O2 consumption, predicts mortality in cystic fibrosis (CF). People with CF exhibit skeletal muscle dysfunctions that may contribute to an imbalance between O2 delivery and utilization. Sildenafil, a phosphodiesterase type 5 inhibitor, increases blood flow and improves O2 consumption, although the exact mechanisms in CF have yet to be elucidated. Thus, we hypothesized that exercise intolerance in CF is limited primarily by an impaired skeletal muscle O2 utilization, and sildenafil improves exercise tolerance in CF by addressing this mismatch between O2 demand and extraction.