Open AccessExercise Training Reverses Lipotoxicity-induced Cardiomyopathy by Inhibiting HMGCS2
Author(s) -
Shengcun Li,
Xinming Qian,
Jiahong Gong,
Jie Chen,
Wenzhan Tu,
Xiaolong Chen,
Maoping Chu,
Guanhu Yang,
Lei Li,
Songhe Jiang
Publication year - 2020
Publication title -
medicine and science in sports and exercise
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.703
H-Index - 224
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1249/mss.0000000000002453
Subject(s) - lipotoxicity , medicine , endocrinology , cardiomyopathy , fibrosis , cardiac function curve , downregulation and upregulation , apoptosis , muscle hypertrophy , biology , heart failure , obesity , insulin resistance , biochemistry , gene
This study aimed to determine the effect of exercise training on preventing lipotoxic cardiomyopathy and to investigate the role of the 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) and miR-344g-5p in cardiomyocytes.