Open AccessExercise Training Impacts Skeletal Muscle Clock Machinery in Prediabetes
Author(s) -
Melissa L. Erickson,
Zhang Hui,
Jacob T. Mey,
John P. Kirwan
Publication year - 2020
Publication title -
medicine and science in sports and exercise
Language(s) - Uncategorized
Resource type - Journals
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1249/mss.0000000000002368
Subject(s) - medicine , skeletal muscle , endocrinology , prediabetes , per2 , per1 , vo2 max , endurance training , vastus lateralis muscle , type 2 diabetes , diabetes mellitus , heart rate , circadian clock , clock , circadian rhythm , blood pressure
Disruption of the skeletal muscle molecular clock leads to metabolic disease, whereas exercise may be restorative, leading to improvements in metabolic health. The purpose of this study was to evaluate the effects of a 12-wk exercise intervention on skeletal muscle molecular clock machinery in adults with obesity and prediabetes, and determine whether these changes were related to exercise-induced improvements in metabolic health.