Open AccessNrf2 Activation Enhances Muscular MCT1 Expression and Hypoxic Exercise Capacity
Author(s) -
Linjia Wang,
Rong Zhu,
Jiahui Wang,
Siwang Yu,
Jianxiong Wang,
Ying Zhang
Publication year - 2020
Publication title -
medicine and science in sports and exercise
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.703
H-Index - 224
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1249/mss.0000000000002312
Subject(s) - skeletal muscle , medicine , endocrinology , monocarboxylate transporter , chemistry , citrate synthase , sulforaphane , lactic acid , endurance training , antioxidant , hypoxia (environmental) , biochemistry , enzyme , biology , gene , oxygen , transporter , genetics , organic chemistry , bacteria
Skeletal muscle is the major producing and metabolizing site of lactic acid. A family of monocarboxylate transporter (MCT) proteins, especially MCT1 and MCT4, are involved in the lactate-pyruvate exchange and metabolism. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a pivotal coordinator of antioxidant response and energy metabolism, and has been reported to associate with the physiological functions of the skeletal muscle.