Open AccessDysregulated Inflammatory Response Related to Cartilage Degradation after ACL Injury
Author(s) -
Cale A. Jacobs,
Emily R. Hunt,
Caitlin Conley,
Darren L. Johnson,
Austin V. Stone,
Janet L. Huebner,
Virginia B. Kraus,
Christian Lattermann
Publication year - 2019
Publication title -
medicine and science in sports and exercise
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.703
H-Index - 224
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1249/mss.0000000000002161
Subject(s) - proinflammatory cytokine , medicine , cartilage , osteoarthritis , inflammation , bruise , biomarker , acl injury , anterior cruciate ligament , pathology , surgery , anatomy , biology , alternative medicine , biochemistry
Elevated synovial fluid (SF) concentrations of proinflammatory cytokines, degradative enzymes, and cartilage breakdown markers at the time of anterior cruciate ligament (ACL) reconstruction are associated with worse postoperative patient-reported outcomes and cartilage quality. However, it remains unclear if this is due to a more robust or dysregulated inflammatory response or is a function of a more severe injury. The objective of this study was to evaluate the association of the molecular composition of the SF, patient demographics, and injury characteristics to cartilage degradation after acute ACL injury.