Open AccessResponse of Liver Metabolic Pathways to Ketogenic Diet and Exercise Are Not Additive
Author(s) -
Tai Yu Huang,
Felicia Goldsmith,
Scott Fuller,
Jacob Simon,
Heidi M. Batdorf,
Matthew C. Scott,
Nabil Essajee,
John Brown,
David H. Burk,
Christopher D. Morrison,
Susan J. Burke,
J. Jason Collier,
Robert C. Noland
Publication year - 2019
Publication title -
medicine and science in sports and exercise
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.703
H-Index - 224
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1249/mss.0000000000002105
Subject(s) - ketogenic diet , medicine , endocrinology , metabolic pathway , metabolism , epilepsy , psychiatry
Studies suggest ketogenic diets (KD) produce favorable outcomes (health and exercise performance); however, most rodent studies have used a low-protein KD, which does not reflect the normal- to high-protein KD used by humans. Liver has an important role in ketoadaptation due to its involvement in gluconeogenesis and ketogenesis. This study was designed to test the hypothesis that exercise training (ExTr) while consuming a normal-protein KD (NPKD) would induce additive/synergistic responses in liver metabolic pathways.