Open AccessHigh-Frequency Stimulation on Skeletal Muscle Maintenance in Female Cachectic Mice
Author(s) -
Shuichi Sato,
Song Gao,
Melissa Puppa,
Matthew C. Kostek,
L. Britt Wilson,
James A. Carson
Publication year - 2019
Publication title -
medicine and science in sports and exercise
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.703
H-Index - 224
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1249/mss.0000000000001991
Subject(s) - cachexia , endocrinology , medicine , skeletal muscle , stimulation , sarcopenia , myofibril , anabolism , contraction (grammar) , muscle contraction , cancer
Cancer cachexia, an unintentional body weight loss due to cancer, affects patients' survival, quality of life, and response to chemotherapy. Although exercise training is a promising intervention to prevent and treat cancer cachexia, our mechanistic understanding of cachexia's effect on contraction-induced muscle adaptation has been limited to the examination of male mice. Because sex can affect muscle regeneration and response to contraction in humans and mice, the effect of cachexia on the female response to eccentric contraction warrants further investigation.