Open AccessCombined Exercise Training Positively Affects Muscle Wasting in Tumor-Bearing Mice
Author(s) -
Kia Ranjbar,
Riccardo Ballarò,
Quim Bover,
Fabrizio Pin,
Marc Beltrà,
Fabio Penna,
Paola Costelli
Publication year - 2019
Publication title -
medicine and science in sports and exercise
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.703
H-Index - 224
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1249/mss.0000000000001916
Subject(s) - wasting , cachexia , anabolism , medicine , resistance training , endurance training , cancer , sarcopenia , inflammation , catabolism , aerobic exercise , endocrinology , autophagy , muscle mass , biology , metabolism , biochemistry , apoptosis
Cancer cachexia is characterized by loss of muscle mass and function. Increased protein catabolism, inflammation, impaired anabolism, and mitochondrial function markedly contribute to the pathogenesis of this syndrome. Physical activity has been suggested as a useful tool to prevent or at least delay the onset and progression of cancer-induced muscle wasting. Two main types of exercise can be adopted, namely, resistance and endurance training. The present study is aimed to investigate the effectiveness of a combined (resistance + endurance) exercise protocol in preventing/reverting cancer-induced muscle wasting.