Open AccessEffects of Obesity and Exercise on Bone Marrow Progenitor Cells after Radiation
Author(s) -
Russell Emmons,
Matthew Ngu,
Guanying Xu,
Diego HernándezSaavedra,
Hong Chen,
Michael De Lisio
Publication year - 2019
Publication title -
medicine and science in sports and exercise
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.703
H-Index - 224
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1249/mss.0000000000001894
Subject(s) - bone marrow , progenitor cell , haematopoiesis , stromal cell , medicine , endocrinology , immunology , physiology , stem cell , biology , microbiology and biotechnology
The late effects of radiation therapy can have significant consequences for the health and quality of life of long-term cancer survivors. Radiation induces persistent alterations in hematopoietic stem and progenitor cells (HSPC) and the bone marrow environment; however, how relevant host factors such as obesity and exercise differentially regulate HSPC content and the bone marrow environment after radiation exposure remains unknown. The purpose of this investigation was to evaluate how the combination of obesity and exercise training modulates HSPC and their niche after sublethal radiation exposure in mice.