Open AccessEffect of Endurance Conditioning on Insulin-mediated Glucose Clearance in Dogs
Author(s) -
Michael S. Davis,
Raymond J. Geor,
Katherine Williamson
Publication year - 2018
Publication title -
medicine and science in sports and exercise
Language(s) - English
Resource type - Journals
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1249/mss.0000000000001718
Subject(s) - medicine , insulin , endocrinology , bolus (digestion) , lipolysis , insulin sensitivity , glucose uptake , insulin resistance , conditioning , adipose tissue , statistics , mathematics
Physical activity has been shown to improve insulin sensitivity in subjects with insulin resistance, but the effect of athletic conditioning on subjects with normal insulin sensitivity has received less scrutiny. Because strenuous exercise can be limited by the availability of substrates, it is reasonable to hypothesize that conditioning would increase the capacity for muscle uptake of substrates like glucose and to the extent that improvement in this process would include upregulation of the portions of the glucose uptake pathway in muscle, this increased capacity would also be reflected in insulin sensitivity. Therefore, we tested the hypothesis that conditioning for endurance exercise would result in increased insulin sensitivity using elite racing sled dogs.