Open AccessModerate Exercise Enhances Endothelial Progenitor Cell Exosomes Release and Function
Author(s) -
Chao Ma,
Jinju Wang,
Hua Liu,
Yanyu Chen,
Xiaotang Ma,
Shuzhen Chen,
Yanfang Chen,
Ji C. Bihl,
Yi Yang
Publication year - 2018
Publication title -
medicine and science in sports and exercise
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.703
H-Index - 224
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1249/mss.0000000000001672
Subject(s) - ex vivo , progenitor cell , endothelial progenitor cell , stem cell , chemistry , biology , microbiology and biotechnology , biochemistry , in vitro
Exercise has cardiovascular benefits which might be related to endothelial progenitor cells (EPC). Meanwhile, there is evidence suggesting that EPC-derived exosomes (EPC-EX) promote vascular repair and angiogenesis through their carried microRNA (miR)-126. In this study, we investigated whether exercise could increase the levels of circulating EPC-EX and their miR-126 cargo, and by which promote the protective function of EPC-EX on endothelial cells (EC).