Open AccessEfficacy of Exercise and Testosterone to Mitigate Atrophic Cardiovascular Remodeling
Author(s) -
Jessica M. Scott,
David S. Martin,
Robert PloutzSnyder,
Meghan Downs,
E. Lichar Dillon,
Melinda SheffieldMoore,
Randall J. Urban,
Lori L. PloutzSnyder
Publication year - 2018
Publication title -
medicine and science in sports and exercise
Language(s) - English
Resource type - Journals
eISSN - 1530-0315
pISSN - 0195-9131
DOI - 10.1249/mss.0000000000001619
Subject(s) - medicine , cardiorespiratory fitness , cardiology , endocrinology , cardiac function curve , aerobic exercise , heart failure
Early and consistent evaluation of cardiac morphology and function throughout an atrophic stimulus is critically important for the design and optimization of interventions. This randomized controlled trial was designed 1) to characterize the time course of unloading-induced morphofunctional remodeling and 2) to examine the effects of exercise with and without low-dose testosterone supplementation on cardiac biomarker, structural, and functional parameters during unloading.